Tuesday, March 16, 2010
FDA Regulatory Review Position - Adeno-Associated Virus (AAV) and Other Viral Vector Based Gene Therapy Products Expertise
The FDA’s Center for Biologics Evaluation and Research, Office of Cellular, Tissue, and Gene Therapies is recruiting an Interdisciplinary Scientist in the dynamic, highly challenging, and innovative atmosphere of Gene Therapy product review in the Gene Therapy Branch of the Division of Cellular and Gene Therapies (DCGT). In particular, the incumbent will review submissions related to Adeno-associated virus (AAV) based gene therapy products, other viral vectors, and related products. DCGT staff also reviews studies and data in the areas of somatic cell therapies, gene therapies, tissue-engineering, medical devices, combination products composed of cellular and medical device components, stem cells, xenotransplantation, tumor vaccines, and immunotherapy products. The candidate will do regulatory and scientific review of submissions to the FDA, with a focus on the manufacturing and control of gene therapies.
DCGT is strongly committed to bringing FDA and other scientists, patient advocates, and the public together in partnership to develop new therapies for the 21st Century, while protecting human subjects and ensuring product safety. The candidate will be a part of this collaborative and cutting-edge regulatory and scientific environment.
Qualifications: Eligible individuals must be U.S. citizens. Eligible individuals must have also completed a full 4-year course of study in an accredited college or university leading to a bachelor’s or higher degree that included a major field of study. Applicants are preferred to have an M.D. or Ph.D. or equivalent experience. Candidates should have extensive experience working with AAV vectors. Candidates with a virology background are preferred. Additional experience with assay validation, and quality systems including GMPs are also preferred but not required. Candidates should be highly motivated scientists with proven leadership skills. Candidates should also have excellent written and oral communication skills.
Salary Range: Civil Service salary range for GS-13 is $89,033.00- $115,742.00. Salary will be set commensurate with education and experience.
The candidate may also be eligible for the PHS Commissioned Corps.
Location: Rockville, MD
How to Apply:
Candidates should email a resume or curriculum vitae, bibliography, a brief summary of research accomplishments, and the names/contact information for three references by April 23, 2010 to email@example.com. Please reference Job Code: OCTGT-AAV.
The Department of Health and Human Services is an equal opportunity employer with a smoke free environment.
Wednesday, March 10, 2010
Postdoctoral Fellows in Stem Cell Research
In collaboration with H.T. Soh Laboratory at the University of California at Santa Barbara (UCSB), we are inviting applications for postdoctoral research positions in the area of in vitro directed evolution to generate affinity reagents using microfluidics technology. Qualified applicants should have experience in bio-combinatorial technologies (e.g. phage display, cell surface display, mRNA display or RNA/DNA aptamers). This position is located on the UC Santa Barbara campus. Periodic travel to Wisconsin is required.
Interested individuals should send their CV and three references (with addresses and phone numbers) to Dr. James Thomson and Dr. Hyongsok (Tom) Soh.
Sunday, March 7, 2010
Don't Become a Scientist!
Science is fun and exciting. The thrill of discovery is unique. If you are smart, ambitious and hard working you should major in science as an undergraduate. But that is as far as you should take it. After graduation, you will have to deal with the real world. That means that you should not even consider going to graduate school in science. Do something else instead: medical school, law school, computers or engineering, or something else which appeals to you.
Why am I (a tenured professor of physics) trying to discourage you from following a career path which was successful for me? Because times have changed (I received my Ph.D. in 1973, and tenure in 1976). American science no longer offers a reasonable career path. If you go to graduate school in science it is in the expectation of spending your working life doing scientific research, using your ingenuity and curiosity to solve important and interesting problems. You will almost certainly be disappointed, probably when it is too late to choose another career.
American universities train roughly twice as many Ph.D.s as there are jobs for them. When something, or someone, is a glut on the market, the price drops. In the case of Ph.D. scientists, the reduction in price takes the form of many years spent in ``holding pattern'' postdoctoral jobs. Permanent jobs don't pay much less than they used to, but instead of obtaining a real job two years after the Ph.D. (as was typical 25 years ago) most young scientists spend five, ten, or more years as postdocs. They have no prospect of permanent employment and often must obtain a new postdoctoral position and move every two years. For many more details consult theYoung Scientists' Network or read the account in the May, 2001 issue of the Washington Monthly.
As examples, consider two of the leading candidates for a recent Assistant Professorship in my department. One was 37, ten years out of graduate school (he didn't get the job). The leading candidate, whom everyone thinks is brilliant, was 35, seven years out of graduate school. Only then was he offered his first permanent job (that's not tenure, just the possibility of it six years later, and a step off the treadmill of looking for a new job every two years). The latest example is a 39 year old candidate for another Assistant Professorship; he has published 35 papers. In contrast, a doctor typically enters private practice at 29, a lawyer at 25 and makes partner at 31, and a computer scientist with a Ph.D. has a very good job at 27 (computer science and engineering are the few fields in which industrial demand makes it sensible to get a Ph.D.). Anyone with the intelligence, ambition and willingness to work hard to succeed in science can also succeed in any of these other professions.
Typical postdoctoral salaries begin at $27,000 annually in the biological sciences and about $35,000 in the physical sciences (graduate student stipends are less than half these figures). Can you support a family on that income? It suffices for a young couple in a small apartment, though I know of one physicist whose wife left him because she was tired of repeatedly moving with little prospect of settling down. When you are in your thirties you will need more: a house in a good school district and all the other necessities of ordinary middle class life. Science is a profession, not a religious vocation, and does not justify an oath of poverty or celibacy.
Of course, you don't go into science to get rich. So you choose not to go to medical or law school, even though a doctor or lawyer typically earns two to three times as much as a scientist (one lucky enough to have a good senior-level job). I made that choice too. I became a scientist in order to have the freedom to work on problems which interest me. But you probably won't get that freedom. As a postdoc you will work on someone else's ideas, and may be treated as a technician rather than as an independent collaborator. Eventually, you will probably be squeezed out of science entirely. You can get a fine job as a computer programmer, but why not do this at 22, rather than putting up with a decade of misery in the scientific job market first? The longer you spend in science the harder you will find it to leave, and the less attractive you will be to prospective employers in other fields.
Perhaps you are so talented that you can beat the postdoc trap; some university (there are hardly any industrial jobs in the physical sciences) will be so impressed with you that you will be hired into a tenure track position two years out of graduate school. Maybe. But the general cheapening of scientific labor means that even the most talented stay on the postdoctoral treadmill for a very long time; consider the job candidates described above. And many who appear to be very talented, with grades and recommendations to match, later find that the competition of research is more difficult, or at least different, and that they must struggle with the rest.
Suppose you do eventually obtain a permanent job, perhaps a tenured professorship. The struggle for a job is now replaced by a struggle for grant support, and again there is a glut of scientists. Now you spend your time writing proposals rather than doing research. Worse, because your proposals are judged by your competitors you cannot follow your curiosity, but must spend your effort and talents on anticipating and deflecting criticism rather than on solving the important scientific problems. They're not the same thing: you cannot put your past successes in a proposal, because they are finished work, and your new ideas, however original and clever, are still unproven. It is proverbial that original ideas are the kiss of death for a proposal; because they have not yet been proved to work (after all, that is what you are proposing to do) they can be, and will be, rated poorly. Having achieved the promised land, you find that it is not what you wanted after all.
What can be done? The first thing for any young person (which means anyone who does not have a permanent job in science) to do is to pursue another career. This will spare you the misery of disappointed expectations. Young Americans have generally woken up to the bad prospects and absence of a reasonable middle class career path in science and are deserting it. If you haven't yet, then join them. Leave graduate school to people from India and China, for whom the prospects at home are even worse. I have known more people whose lives have been ruined by getting a Ph.D. in physics than by drugs.
If you are in a position of leadership in science then you should try to persuade the funding agencies to train fewer Ph.D.s. The glut of scientists is entirely the consequence of funding policies (almost all graduate education is paid for by federal grants). The funding agencies are bemoaning the scarcity of young people interested in science when they themselves caused this scarcity by destroying science as a career. They could reverse this situation by matching the number trained to the demand, but they refuse to do so, or even to discuss the problem seriously (for many years the NSF propagated a dishonest prediction of a coming shortage of scientists, and most funding agencies still act as if this were true). The result is that the best young people, who should go into science, sensibly refuse to do so, and the graduate schools are filled with weak American students and with foreigners lured by the American student visa.
Professor of Physics Washington University, St. Louis, Mo.
Subscribe to Posts [Atom]